⒈ Significance of red blood cell permeability test
⑴ Increased red blood cell osmotic fragility is seen in: hereditary spherocytosis, autoimmune hemolytic anemia with secondary spherocytosis, etc.
⑵ Reduced red blood cell osmotic fragility is seen in: iron deficiency anemia, globin production disorder anemia, etc.
⒉ Significance of red blood cell incubation osmotic fragility test This test is sensitive to the detection of mild hereditary spherocytosis, and is also seen in pyruvate kinase deficiency and other enzyme-deficient hemolytic anemia.
⒊ Significance of autohemolysis test and correction test
⑴ Hereditary spherocytosis, hemolysis is significantly enhanced in hypotonic saline, hemolysis is significantly corrected after adding glucose, and hemolysis is significantly corrected after adding ATP.
⑵ Congenital non-spherical cell hemolytic anemia type I (G-6-PD deficiency), normal or slightly enhanced hemolysis in hypotonic saline, hemolysis is partially corrected after glucose is added, and hemolysis is partially corrected after ATP is added.
⑶ Congenital non-spherical cell hemolytic anemia type II (PK deficiency), hemolysis in hypotonic saline is significantly enhanced, hemolysis cannot be corrected after glucose is added, hemolysis is significantly corrected after ATP is added.
Which mothers may give birth to babies with incompatible ABO blood types?
1. In the medical history, there is a history of spontaneous abortion and a history of jaundice in the previous baby.
2. The blood type check is O type, and the husband is A, B or AB type.
3. Expectant mothers with type O blood detect those with higher anti-A or anti-B antibody titer before pregnancy.
4. The anti-A(B) IgG titer of pregnant mothers with type O blood>1:64 during pregnancy.
5. B-ultrasound examination during pregnancy, severe hemolysis can show fetal skin edema, hepatosplenomegaly and so on.