The clinical significance of Myoglobin
1. Increased blood and urine myoglobin levels are seen in acute myocardial infarction, which begins to increase at 4 hours after onset and returns to normal at 24 hours. In the urine, it begins to be excreted in the urine at 5~40h and lasts for 3~4d. It can also be found in ischemic heart disease, angina pectoris, myocardial injury, cardiogenic shock, hemorrhagic shock, etc.
2. Elevation is seen in muscular dystrophy, such as Duchenne muscular dystrophy and genetic carriers of the disease (60% to 80% of Mb value increase), congenital muscular dystrophy, myotonic dystrophy, multiple Myositis and dermatomyositis, progressive muscular atrophy, hypothyroidism, drug-induced myopathy [1]. It is used for the early diagnosis of acute myocardial infarction (AMI). Serum Mb begins to rise within 2 to 4 hours after AMI has chest pain, peaks at 5 to 12 hours, and returns to normal at 18 to 30 hours. It can also be used for skeletal muscle diseases, such as rhabdomyolysis, myopathy , Evaluation of malignant hyperthermia, etc.; and monitoring of excessive training in sports medicine, etc.
3. Blood and urine myoglobin levels also increase during renal insufficiency, burns, alcoholism, and diabetic acidosis.